DOI:10.18643/gieu.2014.139
"> DOI:10.18643/gieu.2014.139
"> DOI:10.18643/gieu.2014.139
"/> Is inflammation inducing hypoxic tissue modifications in placenta? A retrospective appraisal
<- Home <- Arhive <- Vol. 10, Issue 4, December 2014



GINECOeu10(4)139-145(2014)
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Is inflammation inducing hypoxic tissue modifications in placenta? A retrospective appraisal

Z. R. Ionescu, M. Sajin, G. C. Oprea, A. V. Dumitru, M. Cîrstoiu, S. Vladareanu


Abstract: Infectious causes of morbidity and mortality in the newborn are well documented, but the relationship of this to placental infection is not well known yet. Having the Ethical Comitee consent for the study, from the medical archives of University Emergency Hospital in Bucharest, Department of Pathology, and the Department of Obstretics and Gynaecology, fifty-seven placentas were selected over a period of 22 months. In this study there have been 15 (26.31%) cases of acute chorioamnionitis (COA) and 31 (73.68%) cases of chronic chorioamnionitis (COC), with an overall mean gestational age of 27.6 weeks. The cases with COA were having mean gestational age of 26.5 weeks (6-38 weeks), only five living new-born with a mean gestational age of 35.3 weeks. In the study, there were documented 10 abortions (17,54%) with a mean gestational age of 12 weeks. Most pathologic cases proved histologic abnormalities such as fibrinoid necrosis of villi, villitis, villous edema, few Hofbauer cells, villous or fetal changes, vasculosyncytial knots, that differentiated the cases from those with normal histology by a increased gestational age with a mean of 32.25 weeks. We conclude that a moderate degree of placental inflammatory status will not influence significantly the degree of hypoxia.
DOI:10.18643/gieu.2014.139

Keywords: placental pathology, gestational inflammation, chorioamnionitis, hypoxia, vasculosyncitial knots, villous edema.

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