<- Home <- Arhive <- Vol. 5, Issue 2, May 2009

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Influence of RAS Polymorphisms on the Development and Perinatal Outcome of Preeclampsia. Genetic RAS Evaluation

L. Procopciuc, G. Caracostea, G. Iordache, I. Olteanu, F. Stamatian

Abstract: The objectives are: 1. to determine the genotype distribution of Met235Thr, Thr174Met, insertion (I)/deletion (D) in the ACE gene, 18-83G/A in the REN gene, 1166A/C in the AGTR1 gene and 3123A/G in the AGTR2 gene in women with and without PE (preeclampsia); 2. to examine the possible influence of RAS gene polymorphisms in the development and perinatal outcome of PE. Forty-five women with PE were included following inclusion and exclusion criteria. The control group comprised 51 normal pregnant women. PCR- RFLP methods were used. The frequency of the TT (M235T), MM (T174M) and D/D (ACE) genotypes was significantly higher (p=0.04; p=0.02; p=0.02) in female patients with PE than in female control subjects. When combined with the TT235 genotype, carriers of the MM174, D/D, AC + CC (AGTR1) or AC+ AA (AGTR2) genotypes had a 6.12; 12.5; 9.2; 5.29- fold increased risk for PE. An increased risk of PE in women carrying the TT235, MM174 and D/D genotypes or combined TT235 and either MM174 or D/D genotypes was observed. There was a significant association of pregnancy outcome with the mutated Met235Thr (AGT), Thr174Met (AGT) and I/D (ACE) genotypes.
Keywords: RAS polymorphisms, preeclampsia, perinatal outcome, PCRRFLP methods

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