"> DOI:10.18643/gieu.2018.62
"> DOI:10.18643/gieu.2018.62
"/> The importance of primary screening in early detection of cervical dysplastic lesions
<- Home <- Arhive <- Vol. 14, Issue 2, May 2018


The importance of primary screening in early detection of cervical dysplastic lesions

H. Saad, A. Braila, R. Velea, M. Braila, C. Lungulescu

Abstract: The cervical cancer prevention involves the identification and the eradication of the precursor and invasive lesions, early, through cytological screening. The lack of screening determines an important increase of the cervical cancer rates in socially disadvantaged women. The cytological screening detects most of the cervical neoplasia in premalignant or early malignant stages, unknown stages of malignancy when evolution under treatment is optimal. The objective of the study was the early detection of the cervical dysplasic lesions with carcinogen potential, through cervical cytology and association with the human pappilomavirus (HPV) testing. Regardless of the class of intraepithelial lesions, the most affected patients were aged between 30-39 years. We have found in small numbers, the existence of positive cases for Chlamydia trachomatis and Mycoplasma genitalium, pathogens involved in the progression of HPV infection. The treatment of the cervico-vaginal infections associated with HPV cervical lesions was specifically targeted, depending on the result of the antibiotic cultures. The cervical cytology examination after the specific treatment showed a decrease in the severity of the cytodiagnostic. Following the cytology study based on the Bethesda cytology, the low-grade squamous intraepithelial lesion class numbered more than half of the patients, 56% followed by the atypical squamous cell (ASC) of undetermined significance, high-grade squamous intraepithelial lession and ASC which cannot exclude a high-grade lesion categories. HPV testing identified the low-risk HPV types 61 and 6, while the high-risk HPV predominated in types 16 and 18. The HPV testing in the primary screening may lead to early diagnosis of high-grade neoplasic lesions. The women with multiple risk factors for cervical cancer require inclusion in screening programs and the setting of prophylactic measures.

Keywords: cervical-vaginal cytology, epithelial cell abnormalities, HPV testing.

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