The benefits of conization in histopathologic diagnosis and treatment of cervical intraepithelial neoplasia

B. Puca, A. Braila, C. Obleaga, M. Braila, C. Lungulescu

Abstract: The notion of cervical intraepithelial neoplasia (CIN) is the lesion of the cervix squamous epithelium, the precursor lesion of invasive cancer, diagnosed by biopsy and histopathological examination. The objective of the study is to evaluate the conization as a biopsy and treatment method, with the entire excision of the lesion together with a safe area in healthy tissue. We have studied a number of 46 patients between January 2017 and May 2018. The patients were between 21 and 70 years of age and were divided into 4 groups: 21-30 years old, 31-40 years old, 41-50 years old, older than 51 years old. The results of the cervical-vaginal cytology test were positive for epithelial cell abnormalities in the Bethesda classification, as follows: atypia of undetermined squamous cells in 8 cases (17%), atypia of squamous cells where a high grade lesion in 5 cases (11%), low-grade squamous intraepithelial lesions in 10 cases (22%), high-grade squamous intraepithelial lesions in 17 cases (37%), atypical glandular cells of undetermined significance in 1 case (2%), cells suggestive of squamous carcinoma in 5 cases (11%). Conization with cold scalp is preferred because it offers tissue samples without compromised edges for histopathological examination, and it is successfully applied in patients with high risk of invasive cancer, cervical carcinoma in situ, CIN 3, adenocarcinoma in situ, extensive lesions and high grade cancer.
DOI:10.18643/gieu.2018.94

Keywords: conization, biopsy, histopathological diagnosis, treatment.