Prevalence and significance of inherited thrombophilia in pregnant patients presenting with intrauterine growth restriction

L. G. Arsene, A. Baros, D. G. Fometescu, O. Munteanu, I. Voicu, M. Cirstoiu

Abstract: This study was undertaken on order to determine if pregnant patients should undergo tests for inherited thrombophilia when intrauterine growth restriction (IUGR) is present. We conducted a study including 343 patients with singleton pregnancy, at the Obstetrics and Gynecology Clinic of the Bucharest University Emergency Hospital, Romania from October 2015 till October 2016, researching and analyzing the correlations between inherited thrombophilia and IUGR, using ultrasound evaluation and blood test samples, as thrombophilic mutations may be a cause for IUGR due to inadequate placental circulation. The patients were distributed in two groups, one comprising patients with no clinical or ultrasonographical signs of IUGR and the other consisting of 29 patients with IUGR, with birth weight below the 10th percentile for the given gestational age. We concluded that MTHFR C677T gene mutation and Factor V Leiden were associated with an increased risk of IUGR, being up to 3 times more prevalent in mothers with fetuses affected by IUGR. Our recommendation states that pregnant patients should undergo tests for inherited thrombophilia when IUGR is present.
DOI:10.18643/gieu.2018.148

Keywords: thrombophilia, pregnancy, intrauterine growth restriction.