<- Home <- Arhive <- Vol. 6, Issue 3, September 2010



GINECOeu6(3)186-191(2010)
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Effect of Hormone Replacement Therapy on Sexual Dysfunction in Postmenopausal Women

C. R. Găleşanu, N. Lisnic, L. Moisii, R. G. Găleşanu, M. Onofriescu


Abstract: In our study, we proved the efficacy of 1 mg Estradiol and 2 mg Drospirenone for menopausal symptoms and increasing sexual act frequency. Forty-two postmenopausal women were randomized 3:1 into two treatment groups. 1. thirty-one women treated with 1 mg estradiol + 2 mg Drospirenone (E2/DRSP); 2. eleven women treated with 1 mg estradiol + 5 mg dydrogesterone (E2/DGS). The period of treatment was six months. The efficacy parameters were the individual relative change of hot flushes, sweating episodes, sleep problems, nervousness, breast swelling, sexual activity. Sexual life, judged by the increase in the number of intercourses/month, has registered a high increase after a six months treatment for both groups, while the difference between the response to the two therapies has been insignificant. The other symptoms of menopause have significantly improved under both treatments. Body weight and breast swelling have registered significant changes only under E2/DRSP. Conclusions: E2/DRSP and E2/DGS were effective in the treatment of climacteric symptoms and improved the sexual activity.
Keywords: menopause, estradiol, drospirenone

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