<- Home <- Arhive <- Vol. 6, Issue 3, September 2010



GINECOeu6(3)198-202(2010)
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46 XY Female with Bilateral Gonadoblastoma

C. R. Dumitrescu, C. Chiriţă, C. Procopiuc, M. Carsote, A. Dumitraşcu, F. Dinu, L. Niculescu, R. Catu, F. Vasilescu, D. Terzea, C. Poiană


Abstract: We report the case of a 17 years old girl, investigated for primary amenorrhea and lack of pubertal development. She had normal height and Tanner stages- P1 B1. The hormonal investigations revealed hypergonadotropic hypogonadism. The CT examination showed a small uterus but no internal gonads. The karyotype was 46 XY and she was diagnosed with Swyer syndrome with streak gonads. Gonadectomy was performed. The histological and immunohistochemical examination showed bilateral gonadoblastomas. Under estro-progestative therapy the evolution was favorable, with regular menses and the development of secondary sexual characteristics.
Keywords: 46 XY female, SRY, gonadoblastoma

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