Failure of Flexible Dose of Recombinant FSH as an Adjuvant to Clomiphene in Consecutive Intrauterine Insemination Cycles

M. B. Cetinkaya, H. S. Celik, Y. T. Alper, M. Tosun, F. D. Bildircin, A. Kokcu, H. E. Malatyalıoğlu

Abstract: The aim of this study was to investigate efficiency of flexible dose of recombinant FSH as an adjuvant to clomiphene citrate and to investigate factors that effect pregnancy rates in couples undergoing consecutive intrauterine insemination (IUI) cycles. Three hundred and seven couples who underwent 580 IUI cycles with ovarian stimulation by clomiphene citrate and/or gonadotropins were analyzed from November 2004 to September 2009, retrospectively. The overall and the clinical pregnancy rates per cycle were 9.8% and 8.3% respectively. There was no pregnancy in 48 cycles which induced with recombinant FSH only as an adjuvant to clomiphene. The only statistically different parameter was the sperm motility between pregnant and non-pregnant groups, but discriminative analysis revealed that this sperm parameter could not be used in the prediction of pregnancy alone. Conclusion. Although combined use of clomiphene citrate and human menopausal gonadotropins are effective in IUI and ART cycles, to support mono-follicular maturation furthermore, adjuvant low dose recombinant FSH does not seem to be helpful in IUI cycles alone.
Keywords: intrauterine insemination, recombinant gonadotropin, pregnancy rate, clomiphene