Coagulation factor deficiency associated with the recurrent abortion

C. A. Ispasoiu

Abstract: Recurrent abortion is defined as three or more consecutive spontaneous abortions before 20 weeks of gestation. The incidence is 0.5-1% of all pregnancies, but the risk of recurrence increases with the number of previous pregnancy failure. Only in 50% of the cases it is possible to identify a causing factor. Most of the cases are due to genetic factors, anatomic abnormalities of the uterus, endocrine factors, infections and immunological factors. Increasingly, however, are discussed the hematological factors, acting either via specific antibodies, or directly, with implications for coagulation and thrombosis process. The fibrinogen deficiencies, the disorders of the Factor XIII and the thrombophilia are still studied and their treatment requires randomized clinical trials for clarification.
Keywords: recurrent abortion, thrombophilia, Factor XIII, fibrinogen