The effects of Ulipristal on surgically induced endometriosis in a rat model

C. A. Huniadi, T. A. Antal, F. Stamatian

Abstract: We conducted a prospective, randomized, controlled, experimental study to evaluate Ulipristal effects on surgically induced endometriosis in a rat model at Experimental Research Center of “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania. According to our knowledge at this moment no clinical or experimental study was published about the effect of Ulipristal on endometriosis. Methods. We used sixty female Wistar albino rats. Endometriosis was induced by transplanting two autologous fragments of uterine horn on bowel mesentery. After induction period we formed two groups: first treated with Ulipristal and second only with the vehicle used for Ulipristal. The volume and mass of the implants were measured, before and after treatment. A pathologist examined microscopically the sections for histological hallmarks of endometriosis. For volumes and masses, Ulipristal reduced the average values meaning that is effective (P=0,01). The treatment induced a more than 50% reduction of the volume and masses of endometrial implants and the histological findings correspond to this. Ulipristal determined regression and atrophy of endometriotic lesions in rats.
Keywords: endometriosis, experimental endometriosis models, Selective Progesterone Receptor Modulator SPRM, Ulipristal