Interleukin 10 gene polymorphisms and recurrent pregnancy loss in Romanian population

V. E. Radoi, C. L. Bohiltea, C. Bara

Abstract: The study objective was to establish an association between interleukin 10 polymorphisms and etiology of recurrent spontaneous abortion (RSA). The genetic polymorphism of interleukin 10 genes were studied by PCR – RFLP in the DNA of 69 women with recurrent pregnancy loss and 64 control women with at least one successful pregnancy and without known pregnancy loss. Our results demonstrated a role for - 819 C/T but not for - 592 C/A and - 1082 A/G IL10 promoter polymorphisms in idiopathic RSA in studied group. Frequency of genotype - 592 CC/ - 819 CC was higher in the control group than in experimental group (p = 0,005). In contrast, genotype - 592 AC /- 819 CT was more frequent in the experimental group (p= 0,05). This study is the first one that demonstrated an association between IL-10 -819 C/T polymorphism in idiopathic recurrent spontaneous abortion among Romanian patients.
Keywords: interleukin, pregnancy loss, polymorphisms