Comparison of the efficacy of seprafilm, interceed, adept, preclude membrane and spraygel in a rat model

C. Y. Sanhal, T. Cirpan, A. M. Ergenoglu, A. O. Yeniel, A. Akdemir

Abstract: To compare the efficacy of five adhesions barrier products with a control group in a rat model. In this randomized controlled animal study, standardized lesions on parietal peritoneum of rats were created by sandpaper and three interrupted sutures. Afterwards, the lesions were treated with Seprafilm,Interceed, Preclude membrane, Adept, SprayGel or no barrier. The resulting adhesions were examined 21 days postoperatively. Adhesion quantity was assessed using a fully quantitative score calculated as the summated which of individual adhesions divided by the width of the traumatized area. Compared to the control group, only SprayGel revealed a statistically significant reduction in adhesion quantity. There were also no statistically significant differences between groups. The promising efficacy of SprayGel (95% decrease in adhesion quantity) warrants the further evaluation of this product in larger human trials.
Keywords: adhesion, barrier, prophylaxis, rat