Is maternal HBsAg carrier status associated with adverse pregnancy outcome?
M. Moga, C. Anastasiu, N. Bâgiu
Abstract: Although various studies have suggested that chronic hepatitis B virus infection is associated with several pregnancy and neonatal complications, the scientific information is still conflicting. Methods. In an attempt to clarify these suppositions we conducted a retrospective case-control study on 52 hepatitis B surface antigen (HBsAg) positive pregnant women (case group) and 111 HBsAg negative women (control group). The main outcome was to evaluate the effect of maternal HBsAg carrier status on pregnancy outcome in terms of preterm birth, preterm premature rupture of membranes (PPROM), prelabor rupture of membranes (PROM), hemorrhagic complications (abruptio placentae, postpartum hemorrhage), fetal weight and Apgar score.
No case of HBsAg vertical transmission was registered, irrespectively of the delivery way. No significantly association was found between HBsAg carrier status and preterm birth (13,21% vs. 20,72%, p=1,24), PPROM (7,69% vs. 9,91%, p=0,63), PROM (18,87% vs. 23,42%, p=0,36), large for gestational age (3,85% vs. 4,50%, p=0,59), small for gestational age (7,69% vs. 6,31%, p=0,38), antepartum hemorrhage (p=0,51), postpartum hemorrhage (p=0,62) and Apgar Score (p=0,72). According to our findings, there is no association between HBsAg carrier status and adverse pregnancy and maternal perinatal outcome.
DOI:10.18643/gieu.2013.8