DOI:10.18643/gieu.2013.83
"> DOI:10.18643/gieu.2013.83
"> DOI:10.18643/gieu.2013.83
"/> Interleukin–20 levels during menopause and relation with obesity
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GINECOeu9(2)83-86(2013)
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Interleukin–20 levels during menopause and relation with obesity

A. M. Malutan, N. Costin, R. Ciortea, C. I. Iuhas, M. P. Rada, D. Mihu


Abstract: We aimed to assess serum levels of interleukin (IL) -20 in menopausal patients and its relationship to nutritional status. A number of 175 women were included in the study and divided into five groups, as follow: control group, pre-menopause group, post-menopause group, surgical menopause group and chronic inflammation group. We evaluated IL-20 serum levels and hormonal profile for each patient including the main steroid sexual hormones(luteinizing hormone, follicle-stimulating hormone, 17β-estradiol, progesterone, dehydroepiandrosterone - DHEA and DHEA sulfate) using Quantakinine Human IL-20 Immunoassay kits, and ELISA sandwich method, respectively. Serum IL-20 levels in women with post-menopause and surgical menopause are significantly lower than in fertile women. In the case of fertile women, IL-20 is positively associated with body weight and body mass index (BMI). However, levels of IL-20 do not show significant differences between women who are overweight and those with normal weight, from the same age group. Women with natural or surgical menopause present significantly lower levels of IL-20, by comparison to fertile women. In the present study a possible association between IL-20 serum levels and menopausal status was investigated. Serum levels of IL-20 showed an association with body weight and BMI in fertile women.
DOI:10.18643/gieu.2013.83

Keywords: menopause, interleukin, overweight, steroid hormones

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