Addressability issues: when is autoimmune thyroiditis a point in the evaluation of spontaneous recurrent abortion in fertile women?

D. Stoian, M. Craciunescu, M. Craina

Abstract: The present study aim to evaluate the impact of autoimmune thyroid disease on recurrent pregnancy loss. Methods. Prospective study, January 2010 - September 2011, screening of 395 cases that came for an endocrinological evaluation, with history of spontaneous abortion. The study group, 241 cases, was analysed by clinical, hormonal, immunological and imagistic means. Results. We identified 53 cases with thyroid disease, 48 with autoimmune thyroiditis. The presence of autoimmune thyroiditis increases the risk of miscarriage up to 3.75 times. Only 13.2% of thyroid ill women were diagnosed prior to our study, despite the 82.15% prevalence of infertility issues. The time span between the last abortion and the present evaluation was around 14.5 months, although 1 out of 5 cases had thyroid autoimmune disease. Presence of thyroid-stimulating hormone anomalies correlated with prevalent abortion. We believe that the best way to screen the patients is to measure all the antithyroid antibodies, ideally before any pregnancy, at least in the first 4-5 weeks of pregnancy.
DOI:10.18643/gieu.2013.184

Keywords: recurrent abortion, thyroid autoimmune disease screening