Predictive markers of intrauterine growth restriction
M. Moga, M. Mihalache, C. Arvatescu, A. Pascu, D. Tint, V. Burtea, C. Anastasiu, N. Bigiu
Abstract: Intrauterine growth restriction is one of the most common and complex problem of the modern obstetrics. Common diseases of the adult as well as obesity, non-insulin dependent diabetes mellitus and cardiovascular disease appear to be related to the abnormal growing in the intrauterine life, in particular with intrauterine growth restriction. This paper aims to review some ultrasound markers (uterine artery Doppler velocimetry) and biomarkers (leptin, adiponectin, endothelin-1, lactate dehydrogenase, s-endoglin, growth factors secreted by placenta: soluble fms-like tyrosine kinase receptor-1, Pregnancy-associated Plasma Protein A, metastin (kisspeptin-54), cited in the literature of the recent years, that can predict uteroplacental insufficiency preceding the fetal intrauterine growth restriction. As an immediate effect, intrauterine growth restriction is associated with perinatal morbidity and increased mortality. Detecting the markers with the highest degree of predictivity, the early identification of this intrauterine fetal vulnerability allows an optimal preventive healthcare actions.
DOI:10.18643/gieu.2014.82