DOI:10.18643/gieu.2014.123
"> DOI:10.18643/gieu.2014.123
"> DOI:10.18643/gieu.2014.123
"/> Glucose-regulated protein 78, an important biomarker in cancer etiopathogenesis
<- Home <- Arhive <- Vol. 10, Issue 3, September 2014



GINECOeu10(3)123-125(2014)
© gineco.eu


Glucose-regulated protein 78, an important biomarker in cancer etiopathogenesis

R. Ciortea, L. Angheluta, D. Pintican, R. Baltoaica, C. Bucuri, A. Malutan, D. Mihu


Abstract: Glucose-regulated protein 78 (GRP78) is a major ubiquitous endoplasmic reticulum (ER) protein expressed in normal cells. It belongs to the heat shock protein (HSP) family and is induced by a variety of stress conditions. In cancer cells, in addition to its location in the ER, GRP78 is also present in the plasma membrane, serving as a receptor for various ligands. Moreover, the amount of expressed GRP78 is directly correlated with tumor invasiveness and can be used as a biomarker for cancer. The interest in GRP78 is based on its different functions, both in normal and pathological conditions. GRP78 is a marker for ER stress. GRP78 is a central regulator of ER stress due to its major antiapoptotic role, as well as to its capacity of controlling the activation of transmembrane ER stress sensor. Recent studies have demonstrated that GRP78 plays an important role in the development, progress and chemoresistance of tumors.
DOI:10.18643/gieu.2014.123

Keywords: GRP78, endoplasmic reticulum, stress, cancer.

Full Text in PDF
© 2008-2024 gineco.eu. All rights reserved
created by if else factory