Biological markers compound with dual-energy X-ray absorptiometry examination in the postoperative prediction of patients with postmenopausal osteoporotic fractures

R. Ene, P. Zsombor, P. Ene, R. Sinescu, M. Cirstoiu, D. Popescu, C. Cirstoiu

Abstract: Osteoporosis is a systemic bone mass loss, a deterioration of the bone microarchitecture, which causes the bone to become more fragile. The most common places of these types of fractures take place on the hip, spine and wrist, but other anatomical regions can be affected as well. The most cost-effective diagnostic method in osteoporosis is the bone mineral density (BMD) determination by dual-energy X-ray absorptiometry. Due to the poor sensitivity of this method, determination of biological markers of the bone turnover has an increasing importance; however, the clinical utility is still limited. The aim of this study is to compare the values of serum and urinary biochemical markers resulted from activities of bone tissue, that provide information of bone metabolism, with the BMD and also osteoporotic fracture predictive ability of the two methods. Between 2011-2013 in the orthopedic department of Bucharest Emergency University Hospital were selected a total of 60 women in postmenopausal that suffered fractures of the femoral neck, pertrochanteric fractures, compaction fractures of the lumbar spine and distal radius fractures. Of the 60 patients, we selected 10 patients considered the results to be representative of the analysis of the correlation between the outcome of BMD and bone metabolism biomarkers level. Assessing the biochemical markers of bone resorption was associated with increased risk of fractures of the hip, spine and fracture of distal radius, independent of BMD.
DOI:10.18643/gieu.2014.146

Keywords: osteoporosis, fracture, biomarkers, bone mineral density.