DOI:10.18643/gieu.2015.24
"> DOI:10.18643/gieu.2015.24
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"/> Does inflammation influence placenta shape? A morphometric analysis regarding trophoblast and intervillous space
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GINECOeu11(1)24-26(2015)
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Does inflammation influence placenta shape? A morphometric analysis regarding trophoblast and intervillous space

Z. Ionescu, G. Ionescu, M. Cirstoiu, O. Bodean, M. Sajin, S. Vladareanu, R. Vasiloiu


Abstract: The aim of this study is the morphometrics in histologic shape changes of placenta with acute and chronic inflammation in pregnant women patients and the comparison of results with normal ones, in order to observe the reaction of trophoblast and intervillous space. We conducted an observational, correlational study of 44 placenta specimens collected from the Gynecology and Obstetrics and from the Pathology departments in the Emergency University Hospital in Bucharest, processed, embedded in paraffin blocks, sectioned 3 µm thick and haematoxilin eosin stained. We found 6 cases (13.6%) with acute chorioamniotitis (CHO), 24 cases (54.5%) with chronic CHO and 14 cases (31.8%) with normal histology, with the overall mean gestational age of 30.34 weeks and mean mother age of 30.86 years old. Percentage measurements of trophoblastic areas and of the intervillous spaces were performed on scaled photographs with the aid of a morphometric software. The statistical Mann-Whitney U test applied on obtained data, proved significant differences in between groups or chronic CHO cases compared with normal (P<0.05), while acute CHO cases proved slight morphologic differences. The main detected feature is that the intervillous space increases and syncytiocitotrophoblastic structures reduces in quantity in chronic inflammatory states of placenta, thus, showing the more rising importance for morphometric studies in pathology and histology.
DOI:10.18643/gieu.2015.24

Keywords: chorioamniotitis, placenta, hypoxia, morphometry, histology, pathology.

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