Rapidly progressive high-grade cervical intraepithelial neoplasia in a Hodgkin lymphoma patient: A Case Report

C. Maier, S. Puia, M. Moisa, M. Mitran, A. Potecă, M. Comănescu, C. Neagu, R. Vlădăreanu

Abstract: The progressive behavior of human papillomavirus (HPV) associated neoplasia in immunossuppressed patients has been clearly demonstrated. Hodgkins disease and its treatment render a patient highly susceptible to persistent HPV and its consequences, thus requiring a more aggressive treatment and a closer follow-up protocol. We present the case of a 41-years old patient diagnosed with nodular sclerosing Hodgkin lymphoma receiving radiochemotherapy regimen. After having completed the oncologic therapy the patient was addressed to our clinic presenting abnormal uterine bleeding; a HPV 16-positive high-grade cervical intraepithelial neoplasia diagnosis was established. We obtained persistent disease after conservative treatment which finally leads us to performing a total hysterectomy. We observed a rapidly progressive course of high-grade HPV-induced neoplasia in a case of Hodgkins disease patient which may represent an accelerated version of untreated neoplasia in the immunocompetent. Screening and prompt treatment are of utmost importance in this group at risk.
DOI:10.18643/gieu.2015.111

Keywords: lymphoma, human papillomavirus, cervical neoplasia.