Cardiovascular and metabolic pathologies associated with endometrial cancer

A. Lungu, I. Rentea, C. Minoiu, A. Pungă, V. Horhoianu, M. Cirstoiu

Abstract: Endometrial cancers are one of the most frequent types of gynecological neoplasia in developed countries. In postmenopausal women, the risk of endometrial cancer is about 20%. In premenopausal women below 45 years, the risk is increased when other risk factors for endometrial cancer is associated. It is know that old age, long-term exposure to estrogens, life in developed countries, obesity and metabolic syndrome are the main risk factors for endometrial cancer. The aim of this study is to analyze if there is an association between a series of cardiovascular and metabolic pathologies and endometrial cancer. We perform a retrospective study using all patients admitted in a university hospital, with gynecological pathologies, on a period of two years. From the total number of cases 3030 were excluded 616 patients with other type of neoplasia (either gynecological or non-gynecological). We analyzed the main cardiovascular and metabolic related variables: age, obesity, menopause, diabetes, renal lithiasis, ischemic heart diseases, hypertension, increased cholesterol levels, changes in the reserve lipids, the presence of varicose veins and related hematological and biochemical parameters. Our study showed a significant association between endometrial carcinoma and diabetes (OR=5.1), renal lithiasis (OR=3.60), ischemic heart disease (OR=5.71), changes in reserve lipids (OR=4.1), hypercholesterolemia (OR=3.96), obesity (OR=3.49), arterial hypertension (OR=5.2), and the presence of varicose veins (OR=3.27). This association cannot be explained by increasing age or obesity alone without other risk factors. However, these are not the only cardio-vascular factors that should be looked for in order to decrease the morbidity and mortality in endometrial cancer.
DOI:10.18643/gieu.2015.119

Keywords: endometrial cancer, metabolic syndrome, obesity, hypertension, risk factors.