Predictive factors for persistent and recurrent cervical dysplasia after loop electrosurgical excision procedure in postmenopausal women

C. Dragosloveanu, R. Vladareanu

Abstract: The aim of this study was to prospectively evaluate the outcomes of conservative treatment for pathological proven CIN2/3 (cervical intraepithelial neoplasia) in postmenopausal women and the risk factors potentially involved in the persistence/recurrence of cervical dysplasia. A prospective cohort study was performed over an 18-months period on 132 post-climax women with CIN2/3 treated by loop electrosurgical excision procedure (LEEP) attending follow-up visits. We assessed the relationship between age, parity, AFSI (age at first sexual intercourse), smoking status, use of oral contraceptives, high - risk human papillomavirus (HR - HPV) status, surgical margins, glandular involvement and risk of persistent/recurrent disease. Unadjusted and adjusted analyses were performed; the combined evaluation of these three factors allows placing patients with LEEP into different categories at risk, thus requiring special attention with a rigorous follow - up protocol and preventing a primarily radical therapeutic approach in this particular age - group.
DOI:10.18643/gieu.2015.123

Keywords: postmenopause, cervical intraepithelial neoplasia, HR – HPV, LEEP.