The Treatment of the Precursor Lesions of the Uterine Cervix

E. Căne, I. George, M. Ionescu, G. Peltecu

Abstract: The aim of the study is to explore the correlation between cytology, colposcopy, HPV status and histopathology in precursor lesions of the cervical cancer. This retrospective study involved a total of 483 women between 19 and 66 years old which undergone NETZ (needle excision of the transformation zone) for cervical dysplasia during 2 years period (2006-2007) in Department of Gynecology, Filantropia Hospital, Bucharest, Romania. Precursor lesions of the cervical cancer are quite frequent among women at fertile age; the highest incidence was between 26 and 40 years old (58,6%). The majority of subjects had low-grade lesions (LSIL) (60,1%). Dysplasia with negative colposcopy is uncommon (2,3%) and usually is correlated with minimal histopathological changes. Among tested patients the great majority were HPV high-risk positive (81,2%) with a direct proportional correlation between severity of the lesion and frequency of the infection. The histopathological examination revealed that the most frequent disorder is CIN II (59,1%); the invasive lesion was identified in 1,3% subjects. The severity of the lesions was directly correlated with age (the mean age of women with inflammatory findings was 33 and with high-grade lesion was 39). Cervical dysplasia is a preneoplastic lesion; cytology, colposcopy, biopsy and also HPV testing are essential investigations.
Keywords: cervical dysplasia, cervical intraepithelial neoplasia, colposcopy, hu man papilloma virus, needle excision of the transformation zone.