New trends in diagnose of polycystic ovarian syndrome
C. Ionescu, I. Tircomnicu, M. Dimitriu, E. Bratila, I. Pacu, N. Bacalbasa
Abstract: Polycystic ovarian syndrome (PCOS) is a heterogeneous condition, is present in 12–21% of women of reproductive age. The Rotterdam Criteria for PCOS require the presence of two of the following criteria: oligo/anovulation, hyperandrogenism antral follicle count (AFC) on ultrasound. The purpose of this paper is to bring new information from recent studies regarding the diagnosis of this disease using anti-Mullerian hormone (AMH) vs. AFC. AMH levels accurately reflect the ovarian follicular reserve and could be considered as an extremely sensitive marker of ovarian aging. Special reference is made to the possible implications of AMH in the pathogenesis of PCOS. The measurement of AMH was made by some clinicians the gold standard for diagnosis of PCOS. Because the serum concentrations of AMH is increased in most patients with PCOS and it is an association between the performance of serum AMH and AFC, has led to compare the performance of AMH levels and AFC in diagnosis of PCOS. With evolving progress in ultrasound device, recent studies have suggested increasing the threshold of AFC to 19 or even 26. The real-time interpretation of two-dimensional ultrasonography may underestimate the absolute number of follicles compared with three-dimensional ultrasound.
DOI:10.18643/gieu.2015.196