Predictive factors of early pregnancy failure. A literature review

C. Bucuri, A. Malutan, R. Ciortea, R. Nicula, C. Mihu, M. Istrate, D. Mihu

Abstract: Embryonic demise is the most common event in the lives of women during theirs reproductive time with a rate of about 25%. The aim of this review is to outline the most important paraclinic and biological prognostic parameters. English language articles containing keywords like “embryonic demise”, “predictive factors” which were searched using Medline and Pubmed. Systematic reviews, retrospective and prospective studies, clinical trials focused on this subject were selected. Informative value of the references of selected articles was used as base for further relevant headlines. Among the most significant reported predictive factors are the distance between the yolk sac (YS) and embryo, also known as the yalk stalk sign, the progesterone and β human chorionic gonadotropine levels. Low levels of biomarkers and abnormal appearance of gestational sac, crown-rump length and YS are considered worst prognostic factors and may lead to a poor outcome.
DOI:10.18643/gieu.2016.95

Keywords: embryonic demise, predictive factors, yolk sac, gestational sac.