Cystic adenomatoid malformation of the lung associated with trysomy 18
C. Ionescu, D. Calin, L. Ples, M. Dimitriu, R. Bohiltea, M. Banacu
Abstract: Cystic adenomatoid malformation of the lung (CAML) is a rare lesion with a common incidence of 1/25000 livebirths to
1/33000 livebirths. We present a case of a 22 weeks pregnancy with CAML type III, a hybrid lesion and no other abnormality
associated with trisomy 18. In CAML hybrid lesion the feeding blood supply was derived from the systemic circulation
mainly aorta, in contrast with the clasical CAML lesion in which the blood supply is derived from pulmonary vessel. Also,
CAML lesion do not have a known genetic defect responsible for its appearence, but an early developmental deficiency
of an unknown cause. The association between CAML lesion and chromosomal abnormality is very rare and in reports
were it was detected a slightly increase minor risc, there were present also some extrapulmonary abnormalities.
DOI:10.18643/gieu.2016.109