Hemolytic disease by isoimmunization in Rh and ABO systems in newborns. A clinical study

C. Frecus, I. Husaru, A. Ungureanu, T.L. Hangan

Abstract: The following study aims are to establish the incidence of the hemolytic disease, the risk factors, clinical forms and the main therapeutic measures in the newborns of Constanta County Emergency Hospital over a period of two years, on a group of 76 newborn infants diagnosed with the Rh and ABO hemolytic disease incompatibility. Out of the76 cases of maternal-fetal incompatibility, 39 newborn infants presented Rh isoimmunization, 20 cases presented ABO isoimmunization, and 17 cases presented group and Rh double isoimmunization. Pathological jaundice was presented in all cases, occurred within 24 hours since birth. Based on the classification of clinical signs and laboratory investigations, patients could be divided in two clinical forms of neonatal hemolytic disease: 9 cases with severe anemia at birth and 67 with severe jaundice and moderate anemia. In this cases, we recommend the use of the guide regarding Rh incompatibility in pregnancy which represents a modern and uniform approach of this pathology at national level, decreasing in this way the number of immunized patients during pregnancy.
DOI:10.18643/gieu.2016.172

Keywords: hemolityc disease, newborn.