I. Popescu, C. Ionescu, M. Dimitriu, R. Bohîlțea, R. Viezuină, B. Davitoiu, I. Pacu
Abstract: Polycystic ovarian syndrome (PCOS) is a fairly frequent syndrome but yet a subject that meets a lot of controversies. We
believe that all controversies surrounding PCOS are due to its heterogeneity and complexity but also to its uncertain
etiology. This review is based on the results of clinical trials and studies published until present. Our aim is to present the
evolution of the perspective on the subject and the controversies still surrounding it. Considering the diagnosis, the majority
of medical community uses the Rotterdam criteria, and Androgen Excess Society considers PCOS a „disorder of androgen
excess or hyperandrogenism” thus including hyperandrogenism as a compulsory criterion in its diagnosis. A number of
theories and hypothesis have been launched over the years regarding the etiology of PCOS, none of them being flawless
or able to explain the entire panel of symptoms. Treatment of PCOS does not address the cause itself but rather focuses
on its effects: either anovulation, oligomenorrhea, effects of hyperandrogenism and metabolic changes. The existing
guidelines are still not specific enough, while personal experience plays a major role in the medical conduct leading
to many controversies. As a result, every PCOS guideline is rather a consensus than a nondisputable fact. Considering
nowadays, there is a persistent need for more and greater studies researching new ideas, new genes, and new therapies.
DOI:10.18643/gieu.2017.42