Benign and malignant cutaneo-mucous pathology induced by human papillomaviruses

I. Sârbu, A. Ion, E. Musa, M. Ioghen, C. Matei, D. Mihăilă, M. Mitran, C. Mitran, M. Tampa, S. Georgescu

Abstract: Human papillomaviruses (HPV) represent a group of deoxyribonucleic acid viruses that contain over 150 distinct types which can cause proliferation of squamous epithelium of the skin and mucous membranes. These viruses are ubiquitous in humans and most often produce benign lesions, such as vulgar warts or condyloma acuminatum. Under certain conditions, depending on the viral strain involved and the susceptibility of the host, HPV can cause dysplastic and neoplastic lesions with fatal potential. Recent research has linked infection with certain HPV strains and cervical cancer, this type of cancer being one of the main causes of mortality in the female population. HPV infection and its clinical implications is therefore a real subject of interest, with potential for the development of numerous therapeutic options. This article aims to look over the main clinical aspects of the lesions produced by HPV and to provide information about the existing anti-HPV vaccines.
DOI:10.18643/gieu.2018.77

Keywords: papillomavirus, wart, cervical cancer, vaccine, condyloma acuminatum.