<- Home <- Arhive <- Vol. 6, Issue 1, February 2010



GINECOeu6(1)17-19(2010)
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Biochemical and osteodensitometric correlations in diagnosis of metabolic bone disturbances of prematurity

L. Blaga, G. Zaharie, C. Georgescu, D. Mihu, M. Matyas, M. Popa


Abstract: The incidence of osteopenia of prematurity varies between 30-60%. The biochemical examinations have a high degree of relativity in diagnosis. Radiological changes appear late. Dual energy X-ray absorptiometry allows a better quantification of bone mass. To evaluate the bone mineral content of premature infants by dual X-ray absorbtiometry and to correlate the values obtained with biochemical values. 55 premature infants and 20 term newborns were included in a prospective study. We measured calcemia, phosphatemia, alkaline phosphatase and total bone mineral content at 40 weeks corrected age for premature infants and 4 days of life for term newborns. 25 premature infants had low DXA parameters. There was a highly positive correlation between hypofosfataemia and DXA values and a highly negative correlation between alkaline phosphatase and DXA values. Biochemical investigations are useful tools for the monitoring of bone mineralization and diagnosis of metabolic bone disease.
Keywords: osteopenia of prematurity, hypophosphatemia, bone mineral content, dual absorptiometry

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