Xestospongin C-sensitive calcium stores and angiotensin II-induced myometrial contraction

O. S. Tica, A. Tica, E. Dun, V. Tica, C. Berceanu, A. Brăila

Abstract: The role of inositol 1,4,5 triphosphate (IP3)-sensitive calcium stores on angiotensin II (AG II)-induced uterine contraction was studied by blocking IP3 receptors with xestospongin C (Xe C). This is for the first time when Xe C is used to evaluate the implication of IP3-sensible intracellular calcium stores, during AG II-induced uterine contraction.
Keywords: endoplasmic reticulum calcium stores, IP3, myometrium, angiotensin II, xestospongine C