<- Home <- Arhive <- Vol. 6, Issue 1, February 2010



GINECOeu6(1)37-40(2010)
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Sequential tibolone versus progestin for premenopausal bleeding

Z. Stefanos, I. Georgios, P. Panagiotis, N. Iordanis, T. Panagiotis, G. Georgios, L. Vasilios, N. Koutlaki, J. Marin


Abstract: The aim of this study was to assess the impact of tibolone compared to dydrogesterone on endometrial thickness, breast density, quality of life and lipid profile status. The double blind prospective-randomized study included forty-six perimenopausal women which were randomly assigned for treatment with either tibolone 2.5 mg/day (22 patients) or dydrogesterone 20 mg/day (24 patients) from day 14 to day 25 of the cycle, for 6 months. All women complained for climacteric symptoms and irregular menstrual cycle at least for the last six months. During the 6 cycles of treatment, there was no significant difference between groups regarding the regularity of the cycles. Similarly, no significant difference was observed between groups regarding endometrial thickness, breast density, levels of estradiol, FSH, progesterone and lipid profiles. Regarding vertigo, mood disorder, depression, loss of libido, dryness of skin and vagina, tibolone therapy was found to be much more effective than progestin.
Keywords: tibolone, dydrogesterone, premenopausal bleeding

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