The value of new immunocitologic marker p16ink4a and citologic, colposcopic and histopathological correspondence for diagnosis of cervical lesions

R. Stănculescu, T. Vlădescu, M. Russu, Z. Ceauşu, J. Marin, A. Cucu, V. Bausic, F. Vasilescu, M. Ceauşu, C. Ardeleanu

Abstract: The study’s objective is to analyze the correlation between colposcopic score, the histopathological weighted score, the p16ink4a immunomarker investigated by immunocytochemistry method and the cytology as determined from liquid based cytology. A prospective study was performed over 60 women with different types of cervical lesions, between September 2008 to September 2009, by using a colposcopic score, a p16ink4a intensity detection by immunocytochemical method and a histopathological weighted score. Data were processed in SPSS 15.0 using the correspondence analysis. Results: The results of correspondence analysis showed a correlation between the results of abnormal cytological categories and colposcopic score, hystopathologic score and also with the intensity score of p16ink4a immunomarker. The study identified the presence of a correlation between the p16ink4a immunomarker score and histopathologic weighted score too. Classical investigations used to assess lesion severity are not mutually exclusive; based on our made out correlations, the current study revealed the presence p16ink4a immunomarker within dysplastic cervical cells and that its overexpression is related to an increased histopathological score.
Keywords: imunomarker p16ink4a, liquid based cytology, colposcopic score, histopatologic weighted score