<- Home <- Arhive <- Vol. 6, Issue 1, February 2010



GINECOeu6(1)47-55(2010)
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Effect of Melatonin on Endometrial Proliferation in Ovariectomized Female Rats

R. Ciortea¹, N. Costin¹, D. M. Groza¹, R. Mocan¹, S. Şuşman², C. Bondor³, C. M. Mihu², D. Mihu¹


Abstract: In the context of endometrial cancer, visceral obesity as a risk factor is associated with a chronic inflammatory process, confirmed by the increase in inflammatory marker levels. At 14 days post-ovariectomy, a time period required for the post-operative validation of ovarian failure, with the experimental induction of artificial menopause, the animals included in the study received estrogen replacement treatment and combined treatment of estrogen and melatonin. The duration of the administered treatment, with products and doses recommended for veterinary use, was 12 consecutive weeks. The combined treatment of estrogen and melatonin compared to estrogen replacement treatment induces a decrease in endometrial proliferation and prevents the appearance of cellular atypias. The presented results suggest that melatonin supplementation can play an important role in the prophylaxis of endometrial cancer in menopause.
Keywords: melatonin, cancer, endometrial proliferation, rats

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