<- Home <- Arhive <- Vol. 6, Issue 2, May 2010



GINECOeu6(2)128-133(2010)
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Is There a Role for Platelet Flowcytometry in the Diagnosis of Severe Thrombocytopenia in Pregnancy?

M. Onisâi, A. M. Vlădăreanu, H. Bumbea, S. Radeşi, A. Nicolescu, I. Voican, M. Ciorăscu, C. Pop, D. Câmpean, F. Anca, I. Badea, V. Horhoianu, R. Vlădăreanu


Abstract: We discuss the case of a 16 years-old woman, approximately seven months pregnant (unmonitored pregnancy), that presented to the Emergency Department with intense hemorrhagic syndrome on skin (disseminated petechial lesions) and mucosa (including nose bleed). Emergency laboratory tests reveal severe thrombocytopenia (less than 10000 thrombocytes/mmc), slight anemia, leucocytosis with neutrophilia, liver cytolysis and signs of slight hemolysis. The first suspicion of diagnosis was preeclampsia/HELLP syndrome. The differential diagnosis is discussed, starting from a presentation of the causes of thrombocytopenia in pregnancy. We highlight the value of platelet functional study - immunophenotyping through flowcytometry, because it particularly oriented us to the positive diagnostic.
Keywords: pregnancy, thrombocytopenia, flowcytometry, preeclampsia/HELLP syndrome, platelet antibodies

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